파란 만장했던 고교시절을 보내고 대학생활을 시작한 짐, 케빈, 오즈, 핀치 그리고 스티플러 이렇게 5명의 친구들은 이제 대학생이 되어 맞게 되는 첫 여름방학을 맞아 고향에서 다시 뭉친다. 아직도 섹스와 예쁜 여자만 집착하는 5명의 말썽꾸러기 친구들은 어떻게 하면 환상적으로 첫 여름방학을 보낼까 궁리를 하던 중에 케빈의 형 조언대로 해변가에 빌라를 빌려 각자의 파트너들과 친구들을 불러 멋진 파티를 열어 그야말로 최고의 추억을 만들 계획을 세우게 된다.
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Jason Biggs
Jim Levenstein
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Thomas Ian Nicholas
Kevin Myers
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Chris Klein
Chris 'Oz' Ostreicher
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Seann William Scott
Steve Stifler
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Eddie Kaye Thomas
Paul Finch
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Alyson Hannigan
Michelle Flaherty
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Shannon Elizabeth
Nadia
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Tara Reid
Victoria 'Vicky' Lathum
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Mena Suvari
Heather
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Natasha Lyonne
Jessica
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Chris Owen
Chuck Sherman
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Eugene Levy
Jim's Father
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Molly Cheek
Jim's Mother
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Lisa Arturo
Amber
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John Cho
John
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Justin Isfeld
Justin
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Eli Marienthal
Matt Stifler
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Casey Affleck
Tom Myers
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Tsianina Joelson
Amy
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Bree Turner
Amy's Friend
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Brian Turk
Trucker
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Joelle Carter
Natalie
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Larry Drake
Natalie's Dad
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Lee Garlington
Natalie's Mom
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Ernie Lively
Sergeant
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Morgan Nagler
Michelle's Friend
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George Wyner
Camp Director
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Matthew Frauman
R.A.
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Brian Lester
Grand Harbor Sheriff
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Kevin Cooney
Doctor
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Marilyn Brett
Bus Driver Lady
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JoAnna Garcia
Christy
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Jesse Heiman
Petey
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Jack Wallace
Enthusiastic Guy
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Nora Zehetner
Girl at Party
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Adam Brody
High School Guy
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Nancy Stone
Mom
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Cole Petersen
Kid
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Paityn James
Female EMT
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Joseph D. Reitman
Male EMT
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Mike Erwin
Cashier
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Robert Peters
Grill Guy
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Jennifer Coolidge
Stifler's Mom (uncredited)
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Laurie Reeves
College Party Girl
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Curt Clendenin
Bystander at Stoplight (uncredited)
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Marco Sanchez
Marco (uncredited)
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Christina Cindrich
Jello-Shot Girl (uncredited)
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Jay Rossi
Deputy
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Adam Herz
Younger Business Suit
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J.B. Rogers
Older Business Suit
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Daniel Spink
Boy with Monkey
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Sandra Luesse
Girl at Party (uncredited)
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Phil Hawn
College Professor (uncredited)
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Tara Rice
Amy's Friend (uncredited)
