우연한 사고로 특별한 능력을 갖게된 피터 파커는 대학생과 슈퍼 히어로의 신분을 오가며 짜릿한 생활을 하지만 사랑 하는 메리 제인에게조차 자신의 마음을 열 수 없는 현실은 그들을 안타까운 로맨스로 이끈다. 한편 스파이더맨에게 아버지를 잃고 복수심에 불타는 피터의 친구 해리가 연구 중 폭발로 기계촉수와 엄청난 파워를 갖게된 닥터 옥토퍼스에게 뿌리치지 못할 제안을 하면서 도시 전체가 걷잡을 수 없는 위험에 휘말리게 되고, 스파이더맨의 운명은 점차 예측불가능한 상황으로 전개되는데...
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Tobey Maguire
Peter Parker / Spider-Man
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Kirsten Dunst
Mary Jane Watson
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James Franco
Harry Osborn
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Alfred Molina
Otto Octavius / Doctor Octopus
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Rosemary Harris
May Parker
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J.K. Simmons
J. Jonah Jameson
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Donna Murphy
Rosalie Octavius
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Dylan Baker
Dr. Curt Connors
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Daniel Gillies
John Jameson
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Bill Nunn
Joseph 'Robbie' Robertson
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Vanessa Ferlito
Louise
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Aasif Mandvi
Mr. Aziz
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Willem Dafoe
Norman Osborn
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Cliff Robertson
Ben Parker
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Ted Raimi
Hoffman
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Elizabeth Banks
Miss Brant
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Bruce Campbell
Snooty Usher
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Gregg Edelman
Dr. Davis
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Elya Baskin
Mr. Ditkovich
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Mageina Tovah
Ursula
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Daniel Dae Kim
Raymond
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Joel McHale
Mr. Jacks
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Kelly Connell
Dr. Isaacs
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Christine Estabrook
Mrs. Jameson
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Hal Sparks
Elevator Passenger (uncredited)
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Stan Lee
Man Dodging Debris (uncredited)
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Brent Briscoe
Garbage Man (uncredited)
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Emily Deschanel
Receptionist (uncredited)
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Scott Spiegel
Man on Balcony (uncredited)
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Molly Cheek
Society Woman (uncredited)
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John Paxton
Houseman (uncredited)
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Joy Bryant
Woman at Web (uncredited)
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Joanne Baron
Skeptical Scientist (uncredited)
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Peter McRobbie
OsCorp Representative (uncredited)
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Peter Vouras
Stage Manager (uncredited)
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Donnell Rawlings
Pizza 'Heist' Witness (uncredited)
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Louis Lombardi
Poker Player (uncredited)
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Roshon Fegan
Amazed Kid (uncredited)
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Brendan Patrick Connor
Theater Traffic Cop (uncredited)
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Reed Diamond
Algernon (uncredited)
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Dan Callahan
Jack (uncredited)
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Elyse Dinh
Violinist (uncredited)
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John Landis
Doctor (uncredited)
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Tim Storms
Chainsaw Doctor (uncredited)
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Michael Edward Thomas
Man at Fire (uncredited)
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Anne Betancourt
Woman at Fire (uncredited)
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Joe Virzi
Fireman (uncredited)
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Tom Carey
Train Conductor (uncredited)
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Phil LaMarr
Train Passenger (uncredited)
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Michael Arthur
NYPD Officer (uncredited)
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Frank Bonsangue
Pizza Man (uncredited)
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Cindy Cheung
Chinese Daughter (uncredited)
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Calvin Dean
Boomer (uncredited)
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Andre M. Johnson
Fireman 2 (uncredited)
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Peter Cincotti
Piano Player in Planetarium (uncredited)
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Peyton List
Little Girl Playing on Steps (uncredited)
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Spencer List
Little Boy Playing on Steps (uncredited)
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Troy Metcalf
Blue Collar Guy (uncredited)
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Bonnie Somerville
Screaming Woman (uncredited)
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Garrett Warren
Bearded Doctor (uncredited)
