부두교의 주술을 부리던 검은 수염은 다리가 한쪽인 남자에게 죽게 된다는 예언을 듣게 된다. 자신의 수명을 늘리기 위해 검은 수염은 젊음의 샘을 찾으러 떠나고, 바르보사 또한 검은수염에게 복수를 하기 위해 그를 뒤쫒는다. 한편 영국에서 블랙펄의 선장이 선원을 모집한다는 소문을 듣게 된 잭 스패로우는 자신을 사칭하는 사기꾼을 잡으려다 영국 왕실에 체포되고, 영국의 국왕은 잭 스패로우에게 젊음의 샘으로 가는 길을 안내하라고 명령하고, 이에 필요한 선장과 배, 선원을 모두 내 주겠다고 하는데...
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Johnny Depp
Captain Jack Sparrow
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Penélope Cruz
Angélica
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Geoffrey Rush
Captain Hector Barbossa
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Ian McShane
Captain Edward "Blackbeard" Teach
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Kevin McNally
Gibbs
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Sam Claflin
Philip
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Astrid Bergès-Frisbey
Syrena
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Stephen Graham
Scrum
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Keith Richards
Captain Teague
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Richard Griffiths
King George
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Greg Ellis
Groves
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Damian O'Hare
Gillette
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Óscar Jaenada
The Spaniard
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Anton Lesser
Lord John Carteret
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Roger Allam
Prime Minister Henry Pelham
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Judi Dench
Society Lady
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Christopher Fairbank
Ezekiel
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Paul Bazely
Salaman
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Bronson Webb
Cook
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Richard Thomson
Derrick
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Yuki Matsuzaki
Garheng
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Robbie Kay
Cabin Boy
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Steve Evets
Purser
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Ian Mercer
Quartermaster
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Deobia Oparei
Gunner
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Gemma Ward
Tamara - First Mermaid
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Sebastian Armesto
King Ferdinand
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Juan Carlos Vellido
Spanish Sea Captain
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Tristan Laurence Perez
Spanish Fisherman
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Gerard Monaco
Spanish Officer
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Luke Roberts
Captain of the Guard
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Daniel Ings
Guard
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Emilia Jones
English Girl
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Patrick Kennedy
English Father
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Jody Halse
Jailor
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Clifford Rose
Bailiff
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Paul Hunter
Foreman
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Antoinette Kalaj
Mermaid
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Derek Mears
Master-at-Arms
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Danny Le Boyer
Yeoman
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Steve Morphew
Courtroom Heckler
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Fileena Bahris
Mermaid (uncredited)
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Gintare Beinoraviciute
Villager (uncredited)
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Nicola Bertram
English Woman (uncredited)
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Bern Collaço
Spanish Commanding Officer (uncredited)
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Matt Lasky
Queen Anne's Pirate (uncredited)
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Nichola Fynn
Flower Seller (uncredited)
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Randy Herman
Spanish Soldier (uncredited)
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Bobby Holland Hanton
English Guard (uncredited)
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Harley Jay
Junior British Officer (uncredited)
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Jeremy King
Beckett's Guard (uncredited)
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Teresa Mahoney
Hero Mother (uncredited)
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Edward Mitchell
Young Spanish Officer (uncredited)
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Siegfried Peters
British Sailor (uncredited)
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Steve Saunders
Pewter Seller (uncredited)
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Santi Scinelli
Spanish Officer (uncredited)
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Kristen StephensonPino
Mermaid / Body (uncredited)
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Loretta Walsh
English Girl (uncredited)
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Claira Watson Parr
Maid (uncredited)
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Chuck Williams
Queen Anne's Revenge Pirate (uncredited)
